peprotech Recombinant Human FGF-4細(xì)胞生長因子

產(chǎn)品編號(hào):

100-31

別名:

Fibroblast Growth Factor-4, HST-1, Transforming protein KS3, HBGF-4

描述:

FGF-4 is a heparin-binding growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-4 signals through the FGFR 1c, 2c, 3c, and 4. Recombinant Human FGF-4 is a 19.7 kDa protein consisting of 182 amino acid residues.

peprotech Recombinant Human FGF-4細(xì)胞生長因子

氨基酸序列:

GRGGAAAPTA PNGTLEAELE RRWESLVALS LARLPVAAQP KEAAVQSGAG DYLLGIKRLR RLYCNVGIGF HLQALPDGRI GGAHADTRDS LLELSPVERG VVSIFGVASR FFVAMSSKGK LYGSPFFTDE CTFKEILLPN NYNAYESYKY PGMFIALSKN GKTKKGNRVS PTMKVTHFLP RL

來源:

E.coli

純度:

Greater than 95% by SDS-PAGE gel and HPLC analyses.

生物活性:

The ED₅₀ as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 10⁶units/mg.

交叉反應(yīng):

Mouse, Rat, Human, N/A, Pig, Chicken

重組細(xì)胞因子作用：
細(xì)胞因子通過結(jié)合細(xì)胞表面相應(yīng)的細(xì)胞因子受體而發(fā)揮生物學(xué)作用。細(xì)胞因子與其受體集合后啟動(dòng)復(fù)雜的細(xì)胞內(nèi)分子間的相互作用，zui終引起細(xì)胞基因轉(zhuǎn)錄的變化。
參與免疫應(yīng)答與免疫調(diào)節(jié)，調(diào)節(jié)固有免疫和適應(yīng)性免疫應(yīng)答；刺激造血功能；刺激細(xì)胞活化、增殖和分化；誘導(dǎo)或抑制細(xì)胞毒作用，誘導(dǎo)其凋亡。細(xì)胞因子的作用方式：1.自分泌作用。2.旁分泌作用。3.內(nèi)分泌作用。
細(xì)胞因子的作用特點(diǎn)：多效性、重疊性、協(xié)同性、拮抗性和雙重性。

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